甘肃省中医院注射用血栓通临床合理用药分析

发布时间:2021-10-26 18:08:47

龙源期刊网 http://www.qikan.com.cn 甘肃省中医院注射用血栓通临床合理用药分 析 作者:刘效栓 肖正国 刘军刚 来源:《中国中医药信息杂志》2018 年第 06 期 摘要:目的 通过分析影响中药注射剂血栓通临床效益与风险的相关因素,促进临床合理 用药。方法 运用甘肃省中医院医院信息管理系统,选取 2015 年 8 月 1 日-2016 年 8 月 1 日使用 注射用血栓通的患者病历与医嘱,内容包括患者信息、药物信息、药物使用信息。采用 SPSS19.0 统计软件对血栓通临床应用做合理性分析,采用二分类 Logistic 回归分析寻找发生不 良反应的相关因素。结果 共 1229 例患者被纳入研究,10 947 条用药记录。不合理用药主要为 适应证不恰当(21.11%),给药时间长度不合理(1.87%),给药剂量过大(0.9%)。回归分 析显示:①对食物、药物及其他物质有过敏史的患者,应用注射用血栓通后发生不良反应的风 險增加 8.725 倍;②合并用药使注射用血栓通发生不良反应风险增加 1.799 倍;③与消肿止痛 合剂、健胃消食合剂、骨肽注射液、腺苷钴胺、右旋糖酐注射液、多烯磷酰脂胆碱注射液、盐 酸氨基葡萄糖片等联合用药,可能是血栓通注射液发生不良反应潜在的风险因素。结论 注射 用血栓通临床不合理用药因素主要表现在适应证不适宜、给药剂量过大和用药疗程过长;不良 反应的发生主要与患者过敏史、合并用药、给药剂量过大有关。 关键词:注射用血栓通;合理用药;Logistic 回归分析;危险因素 DOI:10.3969/j.issn.1005-5304.2018.06.032 中图分类号:R288 文献标识码:A 文章编号:1005-5304(2018)06-0125-04 Analysis on Clinical Rational Application of Xueshuantong Injection in Gansu Provincial Hospital of Traditional Chinese Medicine LIU Xiao-shuan1, XIAO Zheng-guo1, LIU Jun-gang1, ZHANG Min1, LI Li1, WANG Jiong1, LUO Yan-yan2 1. Pharmacy Department of Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2. Pharmacy College of Gansu University of Chinese Medicine, Lanzhou 730000, China Abstract: Objective To investigate the influence of TCM Xueshuantong Injection on the clinical benefit and risk factors; To promote rational medication. Methods HIS system of Gansu Province Hospital of Traditional Chinese Medicine was used, and the medical records and information of patients who used Xueshuantong Injection from August 1st, 2015 to August 1st, 龙源期刊网 http://www.qikan.com.cn 2016 were selected, including patient information, medicine information, and medicine application information. SPSS19.0 software statistics was used for rational analysis on the clinical application of Xueshuantong; two-class Logistic regression analysis was used to look for adverse reactions related factors. Results Totally 1229 patients with 10 974 medical records were included in the study. Irrational use of medicine was mainly for inappropriate indications (accounted for 21.11%), time of unreasonable administration (accounted for 1.87%), and too large dosage (accounted for 0.9%). Regression analysis showed: 1. Patients with history of allergies to food, medicine, and other substances, increased the risk of adverse reactions 8.725 times after application of Xueshuantong Injection; 2. The medicine combination increased the risk of adverse reaction of Xueshuantong Injection 1.799 times; 3. Medicine combination with Xiaoz

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